Tag Archives: NRF-2


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Glutathione: The Underground Antioxidant

by Sean Croxton

It is called the master antioxidant.

Master detoxifier, too.

It protects every single one of your 50 to 75 trillion cells, including your brain.

The lower your levels of it, the higher your risk of cancer, Parkinson’s, Alzheimer’s, and autoimmunity.

And as of today, a Pubmed search displays 95663 scientific articles on it.

BUT I bet you’ve never heard of it.

Why? Well, maybe because you can’t fortify juices, cereals, and Diet 7-Up with it.

Or maybe because today’s multi-billion dollar antioxidant industry will crumble to its knees once the public catches wind of it.

When it comes to antioxidants, glutathione is as underground as it gets.

Before we jump into exactly what glutathione does, let’s discus why it does it. You have probably heard the phrase “the powerhouse of the cell”. Every time I hear that I flash back to elementary school and the entire class shouting “THE MITOCHONDRIA!”.

The mitochondria’s nickname couldn’t be any more appropriate. Housed within each of your cells, they generate the energy your body runs on by way of utilizing oxygen to convert food into fuel, or what is known as ATP.

Just like your car produces exhaust as a byproduct of the burning of gasoline, the mitochondria’s energy production system creates reactive oxygen species, better known as free radicals.

The mitochondria have a built-in protection system (antioxidant enzymes) to protect themselves from these free radical scavengers. However, 5% escape and wreak havoc on the cell, including damage to the DNA (potentially cancerous), enzymes, and cellular membrane. No bueno!

To get an idea of how these free radicals work, let’s use an analogy I actually heard last night from my friend Blue Elam. If you were to put 10 rambunctious boys into a room with 9 basketballs, what would happen?

First of all, you’d be a cruel, mean person for doing that. But the boy without a ball would steal a ball from another. And then the boy who doesn’t have a ball anymore will steal one from the next boy. And it never stops!

This is exactly what free radicals do. They steal electrons from vital areas of your cells in order to fill their outer shells. This process, called oxidative stress, has been associated with over 200 different diseases and conditions. In fact, a Pubmed search for oxidative stress displays 87374 scientific papers! In some cases, the free radicals cause the disease. In others, the disease causes the oxidative stress.

This is exactly why we have become so enamored with dietary antioxidants in the forms of expensive juices, supplements, and of course, fortification of processed foods.

As we discussed in Tuesday’s blog, dietary antioxidants, while effective, are in fact inferior to the antioxidant enzymes produced by your cells. These enzymes include superoxide dismutase, catalase, and the pound-for-pound antioxidant champ glutathione.

Glutathione is a protein consisting of three amino acids (a tripeptide). Its job is to act as a cellular security guard and protect the cell and mitochondria from free radical damage. When glutathione levels become depleted due to aging, stress, heavy metals, pollution, radiation, poor diet, and more, free radicals run wild. One consequence is the dimming of the lights in your cellular powerhouse. In other words, your energy production slows down. Is it any wonder why we have an epidemic of Chronic Fatigue Syndrome!

Glutathione works in conjunction with dietary antioxidants. It breathes new life into the water-soluble vitamin C, which then interacts with the fat-soluble vitamin E and CoQ10 (also vital for energy production), helping to keep antioxidant levels of those intact. (Perricone, 35)

If you’re taking a handful of vitamin supplements every day, you’ll be well served to boost your glutathione levels to keep them hanging around for longer.

In a nutshell, glutathione is what I call the bomb!

But don’t take my word for it.


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Top 3 Foods that Turn the Good Genes ON!

by Sean Croxton

NOTE: If you haven’t read yesterday’s blog, this one won’t make much sense to you. Check it out HERE!

“Finding substances that can turn ON the highly protective transcription factor NRF2 holds the key to preventing a host of diseases.”

A few months ago, I stood in an aisle at Borders and stumbled across that line in the book Forever Young by Dr. Nicholas Perricone.

After reading it, I didn’t know what to do with myself. I took out my iPhone and started taking pictures of the passage and texted them to my friends and critics. I posted the quote to Facebook. I thought:

“FINALLY, somebody gets it!”

I had just spent the previous months taking a bit of a beating for my Protandim endorsement. However, regardless of the hate mail and “unsubscribes” from my YouTube channel and email list, I knew I was helping people.

I also learned a lesson I would never forget, that it’s better to educate your people on how something works BEFORE selling it to them. On top of that, I may want to NOT follow a series of anti-genetic modification videos with a bunch of hype over a supplement that alters gene expression. Kinda easy to confuse the two.

Whoops.

Being the Just Eat Real Food guy, the endorsement of a supplement appears antithetical to the overall message of sticking to Nature, no matter how natural the product may be. We should be able to get everything we need from food, right?

Absolutely. But to hit the switch and turn ON your disease-protective NRF2 transcription factor (as this supplement is scientifically-proven again and again to do), you’re going to have to consume a very specific set of foods on a regular basis.

The Big 3 NRF2 switch-flippers we will be exploring today are teas, cinnamon, and turmeric. You can probably find all three in your kitchen cabinet. Personally, I’m not a tea guy. But cinnamon and turmeric never go missing from my ever-growing spice collection.

Here’s why YOU should add them to your diet.


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Nutrigenomics: Hittin’ Switches!

by Sean Croxton

“I’m hittin’ switches all day…”

That first line from one of my favorite gangsta rap songs perfectly captures the spirit of today’s blog.

Nutrigenomics is a topic that sparked my interest almost two years ago when I began skeptically investigating a certain supplement and its claims. Eventually, it led me to such classic books as Deep Nutrition, The Primal Blueprint, Genetic Nutritioneering, and now Forever Young by Dr. Nicholas Perricone.

Nutrigenomics is exactly as it sounds. It is the combination of nutrition and genomics. In other words, it is the study of how nutrients and other substances influence the expression of our genes.

For some, genetics unfortunately hold us hostage. Many of us erroneously assume that our genes are all-powerful, leaving our health at the mercy of our genetic blueprints. For example, my father and his mother both died of pancreatic cancer. Two generations of such a ruthless disease should have me quaking in my Nikes.

But what should I do? Should I just count down the days, months, or years until I get the formal diagnosis?

Hell no.

I hit switches.

Music, please!!

The switches I hit turn my good protective genes ON and my bad genes that cause cancer and other diseases OFF.

You can do it too! And we can all do it through the foods we eat and/or the supplements we take.

The public, media, and medical professionals always tend to lag about twenty years behind the scientific research. One thing that we haven’t quite caught on to is the fact that the benefits of foods go well beyond ORAC values, antioxidant profiles, and macronutrient ratios. Nutrients like catechins, polyphenols, and stilbenes actually affect gene expression.